Al Fin, You Sexy Thing!

31 December 2006

Bremelanotide for Female Sexual Dysfunction--Phase 2 Trials

As Bremelanotide gets closer to phase 3 trials, you can sense the revolution building. Some feminists thought Viagra was the revolution, but feminists have no real imagination. Bremelanotide is going to hit modern developed societies like no other drug since the contraceptive pill.

Palatin Technologies, Inc. (Amex: PTN) and King Pharmaceuticals, Inc. (NYSE: KG) announced today that the companies have completed enrollment in the pre-menopausal cohort of a Phase 2 "at-home" clinical trial evaluating bremelanotide in pre- and post-menopausal patients experiencing female sexual dysfunction (FSD). The FSD clinical trial is designed to evaluate the initial multiple-dose safety and efficacy of bremelanotide in both pre- and post- menopausal women, and will provide the companies with information that will guide selection of clinical endpoints and estimates of treatment effect size for future clinical trials. The results from this trial are anticipated to be released in calendar year 2007. Bremelanotide is a drug candidate for the treatment of male and female sexual dysfunction and is being developed for regulatory approval and commercialization by Palatin and King Pharmaceuticals.
Source.

Bremelanotide is the first compound in a new drug class called melanocortin receptor agonists under development to treat sexual dysfunction. This new chemical entity is being evaluated in Phase 2 clinical trials studying the efficacy and safety profile of varying doses of this novel compound in men experiencing erectile dysfunction (ED) and women experiencing female sexual dysfunction (FSD). The mechanism of action of bremelanotide may offer important benefits over currently available products for the treatment of ED because it acts on the pathway that controls sexual function without acting directly on the vascular system. Clinical data indicates that bremelanotide may be effective in treating a broad range of patients suffering from ED.
Source.


The birth control pill separated sex from procreation. The subsequent sociological revolution from that severance has been incalculable. The true aphrodisiacs will separate sexual desire/response from natural preference. In other words, "I'm not in the mood" will prompt the opening of the drug cabinet, instead of a long sexless night.

Rohypnol and alcohol are date rape drugs because they lower the woman's defenses against unwanted sex substantially. Bremelanotide will go much further--it will not only lower the defenses, it will open the gates wide.

Since the issue of the malleability of "free will" is one the FDA may not wish to consider, it is possible the courts will get involved in the final approval of Bremelanotide.

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29 December 2006

Flibanserin: An Aphrodisiac For Women Who Want to Stay Horny, Eventually

Researchers at German drugmaker Boehringer Ingelheim have stumbled upon a drug that may be another sex drive booster that works in women. The scientists were looking for a new fast acting anti-depressant, but incidentally discovered that the drug--flibanserin--generated a surge of sexual desire in many women subjects.

Like all companies working on antidepressants, Boehringer surveyed patients in its clinical trial to assess dampening of libido, a well-established side effect. Far from complaining about a drop in sexual desire and arousal, many of the women in the trial reported a surge.

The men had no such response—and neither group showed any improvement in mood. "It is an interesting drug," says Dr. André T. Guay, director of the Center for Sexual Function at the Lahey Clinic Northshore, Peabody, Mass., and assistant professor at Harvard Medical School. "These things come about in strange ways."

...."This is not something that can be taken on a Friday for the weekend," says Boehringer Ingelheim spokesman Mark R. Vincent. "There is a gradual increase in sexual desire over a six- to eight-week period."

Pinning down the mechanism is especially critical, in this case, because the FDA views drugs that affect the complicated central nervous system with extra caution.
Source.

The interesting thing about flibanserin is that the libido effect occurs only after several weeks of taking the drug. Presumably, then, the libido effect would continue indefinitely as long as the woman continued taking the antidepressant-cum-aphrodisiac? Time will tell.

The other drug currently in the pipeline with the ability to boost a woman's (and men's) libido, is Bremelanotide.

Some are calling the new female libido boosters "viagra for women", but that only demonstrates their ignorance of both how Viagra works and what it actually does for men--which has little to do with sex drive, and everything to do with the mechanics of joinery.

While women might look forward to flibanserin working its slow way through the drug approval process, men will need to focus their sights on Bremelanotide.

Hat tip Pharmagossip.

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22 December 2006

1TrackMind 13: Persistent Orgasm Syndrome, Panty Shield, BeautifulAgony.com

Danielle reports on a new disease that afflicts women with constant orgasms – but Lou thinks it’s a hoax. Plus they report on the soldier in Iraq who carries his wife’s panties into battle. Finally, when they review BeautifulAgony.com – where members upload videos of themselves having an orgasm.

Thanks to 1TrackMind for the video followup on two of our most recent posts here at AFYST.

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20 December 2006

Female Orgasm--Beautiful Agony

A wonderfully expressive example. Put on some music. Watch it unfold, like a rosebud.

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The Science of Orgasm

To most people, orgasms are something to be experienced intensely and often--not an object of scientific study. But Neuroscientist Barry R. Komisaruk, Endocrinologist Carlos Beyer-Flores, and nurse specialising in sexuality Beverly Whipple, wanted to look into the subject much more deeply.

Authors Komisaruk and Whipple had previously published a study titled "Functional MRI of the Brain During Orgasm in Women". In that study, the authors first discuss various peripheral stimuli inducing orgasm in men and women. Then they discuss the amazing phenomenon of women with complete spinal cord interruption who are able to achieve orgasm through digital vaginal/cervical stimulation! The orgasmic activity is demonstrated in the brain by fMRI.

Their more recent book is obviously much more comprehensive, and is receiving some extremely favourable reviews from many quarters.

"In considerable but lucid detail, three researchers from different fields address every aspect of the science behind orgasms, from why they feel so good to whether transsexual men with surgically created vaginas can have them."— New Scientist

"Approach the book with any question you can conjure about the whys and wherefores of orgasm and you'll receive a minutely detailed answer that incorporates findings from the latest sex research."— Psychology Today

"Behind its tongue-in-cheek 'plain brown wrapper' cover, this unique book offers a thorough compilation of what modern science, from biomechanics to neurochemistry, knows about the secrets of orgasm."— Publishers Weekly

"Of the many aspects of our sexuality, the unique experience of orgasm remains the most mysterious. This intriguing book sheds light on that mystery and reveals what is known and unknown about the orgasmic process. Anyone with an interest in sexuality should own this book."—John Bancroft, The Kinsey Institute for Research in Sex, Gender and Reproduction

"Destined to be a classic in human sexuality. A comprehensive guide to one of life's greatest pleasures. A must read!"—Hilda Hutcherson, M.D., Columbia University, author of What Your Mother Never Told You About Sex

"Orgasms are electrifying and mysterious. Why do orgasms feel so good? What inhibits them? Do men's and women's orgasms differ? How many kinds are there? Does aging affect orgasm? I was delighted to find the answers to these and many more questions in this engaging book. An intriguing read—that just might improve your health and change your life."—Helen Fisher, Ph.D., author of Why We Love

"As someone who has long cared about sexual health, I found this book to be of immense value. Well-written and enjoyable to read, this book lays out the bases for orgasm disorders, sexual problems, the effects of specific illnesses on orgasm, and how drugs and hormones affect the orgasmic process. With refreshing insights into what makes sexuality a healthy and pleasurable life process, this book belongs in the hands of anyone who wants to know more about this integral part of sexual health."—David Satcher, 16th Surgeon General of the United States

"Those with real faith in science as an exit route from dysfunction might want to check out The Science of Orgasm."— Elle


Such thorough analyses of the sexual orgasm are necessary in order to devise ways of helping the many people who suffer from various types of sexual dysfunction, and--PC Alert!--perversion (pedophilia, necrophilia etc.).

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03 December 2006

I Thought It Was Normal At The Time . . .

Persistent Sexual Arousal Syndrome. Some women with the problem consider it a form of suffering:

a 71-year-old called Lila, told how everything from dinner parties and car journeys to just sitting on the sofa was torture.

She moaned: “It’s just a horror. This never stops, it never lets up. It colours your whole life.”

Lila said she often had 200 small orgasms a day since undergoing brain and bladder surgery four years ago.

Fellow American Jean Lund, 51, said medics had only just begun to take the condition seriously.

When she told her gynaecologist he sniggered: “You’re every man’s dream.”

Office manager Jean stormed: “I wanted to punch him. I looked him in the face and said, ‘How would you like to walk around on the verge of orgasm every second?’ And he shut up.”


When I was in my late teens and early twenties, that's how I felt too. Imagine trying to concentrate on a lecture on biostatistics or hematology when the brain between your legs is sending out an overpowering message of a different nature? I just thought it was normal. My girlfriends at the time never complained, either. Well, not much.

I can understand why more mature women who thought they were beyond all that might be troubled by such overwhelming sensations. Strong sexual sensations are distracting. Evolution made them that way, so that the species would not go extinct.

The drug researchers who are developing Bremelanotide as the first truly effective aphrodisiac without serious side effects might consider the sufferers of PSAS when they design the duration of action into the drug formulation.

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